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Table 1 Clinical and pathological data and mutational status of 33 primary GISTs with known recurrent lesions

From: Massively parallel sequencing fails to detect minor resistant subclones in tissue samples prior to tyrosine kinase inhibitor therapy

Primary tumour Recurrent lesion
Case No. CD 117 CD 34 BCL2 DOG1 Tumour cell type Sex Age Localisation Primary mutation Case No. Secondary mutation
1 + + + NA Spindle M 80 EGIST 11: p.W557_V559delinsF 1 a 13: p.V654A
2 + + - NA Spindle F 59 Small intestine 11: p.W557_E561del 2 a 13: p.V654A
2 b 17: Y823D
2 c 13: p.V654A
3 + (+) (+) NA Mixed M 45 Stomach 11: p.K550_V555delinsL 3 a 17: p.D820Y
4 + + + NA Spindle F 44 Peritoneum 11: p.W557_V560delinsC 4 a 13: p.V654A
4 b 13: p.V654A
17: p.D820E
5 + + + NA Epitheloid F 66 Peritoneum 11: p.V559A 5 a 13: p.V654A
6 + + + NA Spindle F 28 Small intestine 11: N567_L576delinsI 6 a 17: p.D820G
7 + (+) (+) NA Spindle M 66 Peritoneum 11: p.Q556_W557del 7 a 13: p.V654A
8 + + + + Spindle F 41 Stomach 11: p.[V560G(;)N566D] 8 a 13: p.V654A
9 + + + + Mixed M 44 Stomach 11: p.K550_K558del 9 a 14: p.T670I
10 + NA NA + Spindle M 67 NA 11: p.V559G 10 a 17: p.D820Y
11 + + + + Spindle F 65 Stomach 11: p.V559D 11 a 17: p.N822Y
11 b 17: p.D820E
12 + +   + Spindle M 63 Stomach 11: p.W557_K558del 12 a 13: p.V654A
13 + - + + Spindle F 71 Small intestine 11: p.V559G 13 a 11: p.[V559G;Y578C]; [V559G;D579del]
13: p.V654A
13 b 11: p.[V559G]; [V559G;Y578C]
13: p.V654A
14: p.N680K
14 + + NA NA Mixed F 43 Small intestine 11: p.N567_Y578delinsSCV 14 a 17: p.N822K
15 + - - NA Mixed F 59 EGIST 11: p.D579_H580insQQLPYD 15 a 17: p.D820E
16 + + + + Mixed M 50 Small intestine 9: p.A502_Y503dup 16 a 17: p.N822Y
17 + - - + Epitheloid F 71 Small intestine 11: p.I563_P573del 17 a 17: p.K818_D820delinsN
18 + + + + Spindle F 52 Stomach 11: p.K558_V560del 18 a 17: p.D820Y
19 + + - + Spindle M 65 Stomach 11: p.W557_V560delinsC 19 a 17: p.Y823D
20 + + - + Spindle M 42 NA 11: p.M552_V559del 20 a 14: p.T670E
21 + + + + Spindle F 59 Stomach 11: p.W557_V559delinsC 21 a 13: p.V654A
22 + + - + Spindle M 46 Rectum 11: p.K558_V560delinsS 22 a 13: p.V654A
23 + + + + Mixed M 53 Stomach 11: p.V559G 23 a 13: p.V654A
24 + + + + Spindle M 60 Stomach 11: p.W557_V559delinsF 24 a 17: p.N822K
25 + + (+) NA Mixed M 65 Stomach 11: c.1648-5_1672del 25 a -
26 + - + NA Epitheloid F 75 EGIST 11: p.Y570_L576del 26 a -
27 + - + NA Mixed M 72 Small intestine 9: p.A502_Y503dup 27 a -
28 + + - NA Spindle F 42 NA 9: p.A502_Y503dup 28 a n.n.
29 + + + NA Mixed M 66 EGIST 11: p.M552_K558del 29 a -
30 + + + NA Spindle F 43 Peritoneum 11: p.W557R 30 a 13: p.K642E
13: p.V654A
31 + - + + Epitheloid F 64 Peritoneum 11: p.W557G 31 a 13: p.V654A
11: p.[W557G(;) V569_Y578del]
17: p.N822Y
32 + + + + Spindle F 77 Stomach 11: p.W557R 32 a 17: p.N822K
33 + + + + Mixed M 68 Small intestine 11: p.I563_P577delinsN 33 a 17: p.D820G
  1. NA: Not known. +: Positive staining; (+): Focal positive staining. M: Male; W: Female. n.n.: Not evaluable. EGIST: Extragastrointestinal stromal tumour; a, b, c: Count of recurrent lesions of one case.