Figure 2

Representative histopathological findings of gangliocytic paraganglioma. Legend: (A) Photomicrograph showing a high-power field of the gangliocytic paraganglioma site featuring a dense proliferation of epithelioid cells. Nested and compactly arranged epithelioid cells comprise the majority of the tumor components (H&E staining; magnification: × 100, scale bar represents 300 μm). (B) Photomicrograph showing a low-power field of the gangliocytic paraganglioma site. Epithelioid cells had round to oval-shaped nuclei, inconspicuous nucleoli, and eosinophilic cytoplasm. Spindle-shaped cells surrounded the nests of epithelioid cells and were aligned in a single layer (H&E staining; magnification: × 400, scale bar represents 100 μm). (C) Photomicrograph showing a high-power field of the gangliocytic paraganglioma site revealing sporadic proliferation of epithelioid cells. A chaotic arrangement of epithelioid cells and a predominance of stromal cells, (e.g., smooth muscle cells, vessels, lymphoid follicles, fibrous tissue, and spindle-shaped cells) were confirmed (H & E staining; magnification: × 100, scale bar represents 300 μm). (D) Epithelioid cells showed a random arrangement, and spindle cells in the stroma were arranged in an irregular pattern (H&E staining; magnification: × 400, scale bar represents 100 μm).