From: Pro1170 Ala polymorphism in HER2-neu is associated with risk of trastuzumab cardiotoxicity
SNP | Polymorphism | Codon | Amino acid change | Protein domain |
---|---|---|---|---|
Rs4252633 | G/T | 452 | Trp-Cys | Ligand Binding |
Rs1136201 | A/G | 655 | Ile-Val | Transmembrane |
Rs34602395 | G/T | 703 | Ser-Ile | Tyrosine Kinase |
Rs56366519 | C/T | 738 | Ser-Ile | Tyrosine Kinase |
Rs28933369 | A/G | 776 | Gly-Ser | Tyrosine Kinase |
Rs28933370 | A/G | 857 | Asn-Ser | Tyrosine Kinase |
Rs28933368 | A/G | 914 | Asp-Lys | Tyrosine Kinase |
Rs2172826 | C/G | 927 | Pro-Arg | Tyrosine Kinase |
Rs1058808 | C/G | 1170 | Pro-Ala | Carboxy terminus |
Rs55943169 | A/C | 1186 | Ala-Asp | Carboxy terminus |
Rs36085723 | A/G | 1253 | Val-Met | Carboxy terminus |