Table 5 Factors associated with overall survival - results of a multivariate Cox regression model with the relative dose-intensity entered as a time dependent variable (n = 380)

Gender

Male

1

Female

0.52

0.003

[0.34; 0.80]

Age ^a

<59 y

1

59 - 73 y

1.77

0.153

[0.81; 3.88]

>73 y

2.57

0.070

[0.92; 7.15]

Socioeconomic status ^b (quintile of EDI national scores)

1: highly favoured

1

2: favoured

0.91

0.783

[0.47; 1.78]

3: intermediate level

1.46

0.242

[0.78; 2.73]

4: deprived

0.61

0.171

[0.30; 1.24]

5: highly deprived

0.74

0.429

[0.36; 1.55]

Comorbidity

none

1

at least 1

0.74

0.224

[0.46; 1.20]

Standard International prognostic index ^c (sIPI)

very good

1

good

1.30

0.559

[0.54; 3.15]

poor

2.61

0.041

[1.04; 6.57]

Chemotherapy regimens ^d

R-CHOP21 or R-CHVP21

1

R- CHOP 14

0.57

0.246

[0.22; 1.48]

R- ACVBP

0.97

0.956

[0.32; 2.90]

R-mini CHOP or R-mini CHVP

1.94

0.122

[0.84; 4.48]

other

1.49

0.516

[0.45; 4.99]

Relative dose-intensity (RDI)

RDI ≥85%

1

RDI <85%

3.89

<0.001

[1.86; 8.14]

Place of treatment ^e

Private centres

1

TUMC

1.88

0.068

[0.95; 3.71]

Community hospitals

1.75

0.075

[0.95; 3.25]

Time dependant variables

RDI * Time

0.998

0.024

[0.997; 0.999]