Serine threonine tyrosine kinase 1 is a potential prognostic marker in colorectal cancer

BMC Cancer

Table 3 Multivariate Analyses of STYK1 Expression and Disease-Specific Survival for Stage II and III Patients in the Study Cohort

Variables	Categories	Stage II Patients			Stage III Patients
		HR	95% CI	P value^b	HR	95% CI	P value^b
Age ( years)	≥60 / <60	1.421	0.705-2.865	0.326	1.475	0.883-2.463	0.138
Sex	Male / female	0.956	0.556-1.645	0.872	1.132	0.718-1.784	0.594
Tumor location	Colon / rectum	0.819	0.472-1.420	0.478	1.158	0.729-1.840	0.534
Tumor size (cm)	≥5 / <5	1.324	0.768-2.284	0.312	1.389	0.863-2.235	0.176
Differentiation grade	Poor / well + moderate	0.854	0.325-2.245	0.749	1.680	1.033-2.733	0.037
STYK1 expression^a	High / low	2.472	1.445-4.229	0.001	2.001	1.251-3.200	0.004

Abbreviations: HR, hazard ratio; 95% CI, 95% confidence interval.
^a For STYK1, the median value of the IRS was used as the cut-off point for definition of subgroups (low expression and high expression groups).
^b Bold type indicates statistical significance.

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