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Table 1 Candidate driver genes identified as amplified or deleted in OGCTs, with correlated expression

From: Combined comparative genomic hybridization and transcriptomic analyses of ovarian granulosa cell tumors point to novel candidate driver genes

Chr Gene # of tumors with Function & Implication in cancer if known Ref
Amp Del
14 AKT1 6 0 Known oncogenic kinase, core of one of the most frequently activated survival pathways in human cance. [50]
17 NR1D1 5 0 Ligand-sensitive transcription factor, regulates the expression of core clock proteins; required for survival and proliferation of breast cancers [24]
12 MMAB 4 0 catalyzes the final step for conversion of vitamin B(12) into adenosylcobalamin. Derivatives of the latter are used to image breast, lung, colon, thyroid, and sarcomatous malignancies. [25]
11 TSPAN32 3 0 Membrane protein, regulates T cell proliferative responses. Tetraspanins are implicated in various steps of tumorigenesis. [51]
11 CTSW 2 0 cysteine proteinase up-regulated in Large granular lymphocyte leukemia [52]
12 DGKA 2 0 converts DAG into PA, a second messenger activating multiple signaling pathways implicated in tumorigenesis (i.e. mTOR signaling) [53]
22 RANBP1 3 1* Soluble component of the nuclear pore complex. Oncogenic overexpression of eIF4E induces overexpression of RANBP1 [30]
22 TRMT2A 3 1* cell-cycle regulated protein, one of the 5 immunohistochemical markers in the Mammostrat test used to stratify breast cancers [54]
12 TENC1 2 1* Promotes PI3K/Akt signaling, KD = > decreased proliferation. High expression associated with aggressive hepatocellular carcinoma [26]
16 PIEZO1 2 1* transmembrane protein involved in mechanotransduction. Mediates integrin activation by recruiting R-Ras to the ER, modulating cell adhesion [55]
12 SPRYD3 2 1* SPRY domain containing 3. Not studied na
22 C22orf26 3 2* Not studied - now named PRR34, proline rich 34 na
22 FAM19A5 3 2 postulated to function as brain-specific chemokines or neurokines, acting as regulators of immune and nervous cells. [56]
1 NVL 1* 3 AAA-ATPase, hTERT binding, essential for telomerase assembly. A nucleolar isoform is a component of pre-ribosomal particles [36]
19 C19orf18 0 2 not studied. Identified as significantly binding to oligomeric β-amyloid [57]
14 FAM177A1 0 2 Unknown function. Down-regulated by microRNA124 during neurogenesis. Identified as a target of the E3 ubiquitin-ligase FANCA. [58]
12 LIMA1 0 2 Inhibits actin depolymerization and cross-links filaments in bundles. Putative suppressor of epithelial-mesenchymal transition and metastasis [40]
17 TADA2A 0 2 transcriptional activator adaptor, in the PCAF and ATAC histone acetylase complexes, mediates DNA damage-induced apoptosis and G1/S arrest [44]
5 HSPA4 0 3 Heat shock chaperone of the HSP110 family. Regulates cell proliferation and G1/S progression by releasing transcription factor ZONAB from tight junction sequestration [59]
15 RTF1 0 3 part of the Paf1/RNA polymerase II complex, key regulator of transcription-related processes and cell-cycle progression [34]
  1. *These genes were found altered in the opposite way in the tumor H4, the only recurrent tumor in our cohort.