Figure 1

Recurrent chromosomal imbalances in adult-type ovarian GCTs. The CGH was performed using genomic DNA from the tumor samples co-hybridized with an equimolar mix of 10 ethnically-matched (finnish) DNA samples. Each chromosomal ideogram is depicted with amplifications in red (on the left) and deletions in green (on the right). This compilation includes data from 94 adult-type GCTs from 5 studies, among which 64 contain large-scale alterations. Smallest Regions of Overlaps (SROs), defined when several independent rearrangements point to a common altered genomic region, are likely to contain driver genes involved in tumor progression. Here, SROs are indicated (black horizontal lines) when they involve at least 5 imbalances of the same type (either amplifications or deletions). Details of chromosomal imbalances and co-occurrences identified by the five studies are provided in Additional file 1: Table S1c.