Skip to main content
Figure 2 | BMC Cancer

Figure 2

From: Tenovin-6-mediated inhibition of SIRT1/2 induces apoptosis in acute lymphoblastic leukemia (ALL) cells and eliminates ALL stem/progenitor cells

Figure 2

Tenovin-6 induces activation of p53 in ALL cells. A, Molecular structure of SIRT1/2 inhibitor Tenovin-6. B, REH and NALM-6 ALL cells were treated with increasing concentrations of Tenovin-6 for 24 and 36 hours. Acetylated p53, total p53 protein, and SIRT1 were detected by Western blotting analysis with the indicated antibodies. C, REH and NALM-6 cells were exposed to 1 μM Tenovin-6 for the indicated times, and acetylated p53, total p53 protein, and SIRT1 were detected by Western blotting. D, REH cells were treated with 1 μM Tenovin-6 for the indicated times, and mRNA levels of p53 and its targets-genes p21, Puma, Noxa and Bax were examined by real-time PCR. 18 s rRNA was used as an internal reference.

Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us