Figure 3
From: Frequency and distribution of Notch mutations in tumor cell lines
Copy-number alterations and estimation of the impact of missense mutations on Notch1-4 receptor function using PANTHER cSNP. (A) Schematic illustrations of the NOTCH1-4 receptors, showing the distribution of missense mutations with a subPSEC score lower than −3, i.e. 50% chance to be deleterious. The abbreviations for the Notch receptor domains are explained in the legend of Figure 2. (B) The distribution of deletions and amplifications in the four Notch receptors is shown, with the percentage written to the right of the corresponding bar.