Figure 2
From: Frequency and distribution of Notch mutations in tumor cell lines
Notch receptor mutation spectra for different cancer cell types. (A-E, left side) Mutation spectra for NOTCH1 (A,E), NOTCH2 (B), NOTCH3 (C) and NOTCH4 (D). (A-D, right side) Cell types ordered after mutation frequency for the corresponding Notch receptor. The Notch receptor domains are listed in (A). In (E), previously described mutational hotspots in T-ALL and SCC are marked. LNR = Lin12-Notch repeats, HD = heterodimerization domain, NRR = negative regulatory region, RAM = RBPJκ associated module, ANK = ankyrin repeats, PEST = proline, glutamic acid, serine and threonine rich domain. Indels = Insertions or deletions, Frame Shift Alt = Frame Shift Alterations. Upper aero. tract = Upper aerodigestive tract. Autonomic g. = autonomic ganglia. CNS = central nervous system. The different types of mutations are described at the bottom of the figure. Only mutations in the coding region of the Notch receptor proteins are shown.