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Figure 1 | BMC Cancer

Figure 1

From: Frequency and distribution of Notch mutations in tumor cell lines

Figure 1

Notch components are frequently mutated in established cancer cell lines. (A-B) Overall mutation frequency (percentage mutated cell lines) of NOTCH receptors 1–4, as well as of the three Ras proteins (H/K/N-Ras), ErbB1-4, p53, Patched1-2 and APC, as indicated. In (B), the mutation frequencies are relative to the average coding region size (%/kbp). (C) Mutation frequency of Notch receptors and ligands. (D-E) Mutation frequency of NOTCH receptors 1–4 in cell lines that have been clustered into specific cell types, as indicated. In (D), the relative distribution of the different types of NOTCH receptor mutations is plotted for each cell type. In (E), the relative distribution of mutations in each NOTCH receptor is plotted for each cell type. The number (#) of cell lines for each cell type is specified in (E). Indels = Insertions or deletions (not causing frame shift alterations). Frame Shift Alt = Frame Shift Alterations. bp = base pairs. In (A-C), the mutation frequency for the corresponding gene/genes is indicated above each bar.

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