Table 5 Univariate and multivariate analyses of PFS and OS

Mutation status

All WT

56

5.8

reference

-

reference

-

17.7

reference

-

reference

-

Any MT

10

2.2

3.38 (1.65–6.93)

0.001

2.77 (1.16–6.61)

0.021

5.2

4.94 (2.12–11.5)

<0.001

3.38 (1.19–9.58)

0.022

ECOG PS

0

41

6.0

reference

-

reference

-

31.3

reference

-

reference

-

1-2

25

3.5

2.82 (1.53–5.20)

0.001

1.80 (0.89–3.64)

0.101

9.7

3.41 (1.52–7.69)

0.003

1.62 (0.59–4.42)

0.346

Number of metastasis

1

18

6.0

reference

-

reference

-

15.4

reference

-

reference

-

>2

48

5.1

1.57 (0.82–3.00)

0.17

1.51 (0.73–3.11)

0.268

16.7

1.70 (0.68–4.29)

0.257

1.60 (0.59–4.30)

0.353

Treatment line of anti-EGFR mab

2nd

30

7.6

reference

-

reference

-

17.7

reference

-

reference

-

3rd

36

4.0

1.85 (1.06–3.25)

0.032

1.52 (0.83–2.79)

0.174

15.9

1.43 (0.66–3.10)

0.367

0.97 (0.41–2.29)

0.940

Combination therapy

Yes

47

7.4

reference

-

reference

-

31.3

reference

-

reference

-

No

19

2.6

4.82 (2.49–9.35)

<0.001

2.73 (1.28–5.83)

0.009

10.5

3.31 (1.48–7.41)

0.004

2.03 (0.83–4.96)

0.121