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Table 2 IC 50 and maximum non-cytotoxic concentration to normal cells established for the five pre-selected compounds (4 m, 4bt (dimethylenastron), 4p, 4bc and 4x) and monastrol

From: Impact of kinesin Eg5 inhibition by 3,4-dihydropyrimidin-2(1H)-one derivatives on various breast cancer cell features

Compound IC50(μM) Maximum non-cytotoxic concentration to normal cells (mM)
  MCF-7 MDA-MB-231
4 m 197.3 77.08 1.0
4bt 126.9 17.91 0.8
4p 87.5 68.38 0.4
4bc 234.9 249.5 1.0
4x 276.5 237.4 0.8
Monastrol 110.4 113.9 1.0
  1. These concentrations were determined based on cells treatment for 72 h.