Table 2 IC 50 and maximum non-cytotoxic concentration to normal cells established for the five pre-selected compounds (4 m, 4bt (dimethylenastron), 4p, 4bc and 4x) and monastrol
Compound | IC50(μM) | Maximum non-cytotoxic concentration to normal cells (mM) | |
|---|---|---|---|
MCF-7 | MDA-MB-231 | ||
4 m | 197.3 | 77.08 | 1.0 |
4bt | 126.9 | 17.91 | 0.8 |
4p | 87.5 | 68.38 | 0.4 |
4bc | 234.9 | 249.5 | 1.0 |
4x | 276.5 | 237.4 | 0.8 |
Monastrol | 110.4 | 113.9 | 1.0 |