Figure 2

DHPM derivatives cause severe morphological alterations on breast cancer cells. MCF-7 and MDA-MB-231 cells were treated with the maximum non-cytotoxic concentration to normal cells for 72 h and morphological alterations analyzed under an inverted light microscope. Cells with elongated morphology, adherent to the surface and normal size are shown by arrows. Cells with size reduction, absence of focal adhesion points, rounded morphology and detached from the surface where they had been seeded are shown by arrowheads.