Figure 9

Invasion and migration of tumor cells. Primary (A) and immortalized (B) tumor cells can be seen spread on the fibroblast layer. Tumor cells failed to form groups, preferably dwelling as single cells. Scale bars: 100 μm. CSCC7 cell migration was moderate for fibronectin and more intense for laminin-1 in a Boyden chamber after 24 hours (C). Scale bars: 200 μm, stars indicate significance: ***p < 0.001.