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Table 1 Comparison of dysregulated miRNAs associated with ICC to those reported in the literature

From: A microRNA profile associated with Opisthorchis viverrini-induced cholangiocarcinoma in tissue and plasma

miRNA Function Target Direction this work Tissue Ref
Up-regulated in the literature
Let-7a Cell survival NF2 - Cell lines [50]
miR-21 Apoptosis, proliferation, MBD2, 15-PGDH/HPGD, Up Cell lines, Tissue [10,51-54]
  invasion, metastasis PTEN,PDCD4, TIMP3    
miR-25 Apoptosis DR4 Up Cell lines, Tissue [55]
    (CCT v. N-NT)   
miR-26a Proliferation, colony formation, GSK-3 Down Cell lines, Tissue [56]
  tumor growth   (CCT v. N-NT)   
miR-29b - - Up Tissue [57]
    (Pap. v. N-NT)   
miR-31 Proliferation, apoptosis RASA1 Up Cell lines, Tissue [58]
miR-34b - - Up Tissue [57]
miR-135 - - Up Tissue [57]
miR-141 Proliferation, circadian rhythm CLOCK Up Cell lines [51]
miR-146a - - Up Tissue [57]
    (Pap. v. N-NT)   
miR-192 - - Down Tissue [57]
    (CCT v. N-NT)   
miR-194 - - - Tissue [57]
miR-200a Chemoresistance PTPN12 Up Cell lines [57]
miR-200b Chemoresistance PTPN12 Up Cell lines [51,57]
miR-200c Chemoresistance PTPN12 Up Cell lines [57]
miR-203 - - Up Tissue [57]
miR-210 Proliferation Mnt Up Mouse tissue [59]
    (CCT v. N-NT)   
miR-215 - - - Tissue [57]
miR-221 - - Up Tissue [57]
    (CCT v. N-NT)   
miR-361 - - Up Tissue [57]
    (CCT v. N-NT)   
miR-375 - - Up Tissue [57]
    (CCT v. N-NT)   
miR-421 Proliferation, migration, FXR Up Cell lines, Tissue [60]
  colony formation   (CCT v. N-NT)   
miR-429 - - Up Tissue [57]
miR-582 - - - Tissue [57]
miR-892b - - Up Tissue [57]
Down-regulated in the literature    
miR-29b Gemcitabine sensitivity, apoptosis PIK3R1, MMP-2, Mcl1 - Cell lines [61,62]
miR-34a Cell cycle, proliferation c-Myc Up Mouse tissue [59]
miR-124 Migration, invasion SMYD3 - Cell lines [63]
miR-138 Proliferation, cell cycle, RhoC Up Tissue [64]
  migration, invasion    
miR-144 Proliferation, invasion Pafah1b2 Down Tissue [57]
miR-148a Proliferation DNMT-1 Down Cell lines [65]
miR-200b/c Migration, invasion Rho-kinase2, SUZ12 Up Tissue [66]
miR-204 EMT, migration, Slug, Bcl-2 Down Cell lines, Tissue [67,68]
  invasion, apoptosis   (Pap. v. N-NT)   
miR-214 EMT, metastasis Twist Up Tissue [69]
    (CCT v. N-NT)   
miR-320 Apoptosis Mcl-1 Down Cell lines, Tissue [68]
    (CCT v. N-NT)   
miR-370 Proliferation MAP3K8 Down* Cell lines [70]
miR-373 Epigenetics MBD2 - Tissue [71]
miR-376c Migration GRB2 Down Cell lines [72]
    (CCT v. N-NT)   
miR-451 - - Down Tissue [57]
miR-486 - - Down Tissue [57]
miR-494 Proliferation, cell cycle CDK6 - Cell lines [73]
miR-495 - - Down Tissue [57]
    (Pap. v. N-NT)   
miR-513 - - - Tissue [57]
miR-625 - - Up Tissue [57]
    (CCT v. N-NT)   
miR-1926 - - - Tissue [57]
  1. Unless otherwise stated ‘Direction this work’ refers to the CCT v. D-NT comparison.