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Table 1 Comparison of dysregulated miRNAs associated with ICC to those reported in the literature

From: A microRNA profile associated with Opisthorchis viverrini-induced cholangiocarcinoma in tissue and plasma

miRNA

Function

Target

Direction this work

Tissue

Ref

Up-regulated in the literature

Let-7a

Cell survival

NF2

-

Cell lines

[50]

miR-21

Apoptosis, proliferation,

MBD2, 15-PGDH/HPGD,

Up

Cell lines, Tissue

[10,51-54]

 

invasion, metastasis

PTEN,PDCD4, TIMP3

   

miR-25

Apoptosis

DR4

Up

Cell lines, Tissue

[55]

   

(CCT v. N-NT)

  

miR-26a

Proliferation, colony formation,

GSK-3

Down

Cell lines, Tissue

[56]

 

tumor growth

 

(CCT v. N-NT)

  

miR-29b

-

-

Up

Tissue

[57]

   

(Pap. v. N-NT)

  

miR-31

Proliferation, apoptosis

RASA1

Up

Cell lines, Tissue

[58]

miR-34b

-

-

Up

Tissue

[57]

miR-135

-

-

Up

Tissue

[57]

miR-141

Proliferation, circadian rhythm

CLOCK

Up

Cell lines

[51]

miR-146a

-

-

Up

Tissue

[57]

   

(Pap. v. N-NT)

  

miR-192

-

-

Down

Tissue

[57]

   

(CCT v. N-NT)

  

miR-194

-

-

-

Tissue

[57]

miR-200a

Chemoresistance

PTPN12

Up

Cell lines

[57]

miR-200b

Chemoresistance

PTPN12

Up

Cell lines

[51,57]

miR-200c

Chemoresistance

PTPN12

Up

Cell lines

[57]

miR-203

-

-

Up

Tissue

[57]

miR-210

Proliferation

Mnt

Up

Mouse tissue

[59]

   

(CCT v. N-NT)

  

miR-215

-

-

-

Tissue

[57]

miR-221

-

-

Up

Tissue

[57]

   

(CCT v. N-NT)

  

miR-361

-

-

Up

Tissue

[57]

   

(CCT v. N-NT)

  

miR-375

-

-

Up

Tissue

[57]

   

(CCT v. N-NT)

  

miR-421

Proliferation, migration,

FXR

Up

Cell lines, Tissue

[60]

 

colony formation

 

(CCT v. N-NT)

  

miR-429

-

-

Up

Tissue

[57]

miR-582

-

-

-

Tissue

[57]

miR-892b

-

-

Up

Tissue

[57]

Down-regulated in the literature

   

miR-29b

Gemcitabine sensitivity, apoptosis

PIK3R1, MMP-2, Mcl1

-

Cell lines

[61,62]

miR-34a

Cell cycle, proliferation

c-Myc

Up

Mouse tissue

[59]

miR-124

Migration, invasion

SMYD3

-

Cell lines

[63]

miR-138

Proliferation, cell cycle,

RhoC

Up

Tissue

[64]

 

migration, invasion

   

miR-144

Proliferation, invasion

Pafah1b2

Down

Tissue

[57]

miR-148a

Proliferation

DNMT-1

Down

Cell lines

[65]

miR-200b/c

Migration, invasion

Rho-kinase2, SUZ12

Up

Tissue

[66]

miR-204

EMT, migration,

Slug, Bcl-2

Down

Cell lines, Tissue

[67,68]

 

invasion, apoptosis

 

(Pap. v. N-NT)

  

miR-214

EMT, metastasis

Twist

Up

Tissue

[69]

   

(CCT v. N-NT)

  

miR-320

Apoptosis

Mcl-1

Down

Cell lines, Tissue

[68]

   

(CCT v. N-NT)

  

miR-370

Proliferation

MAP3K8

Down*

Cell lines

[70]

miR-373

Epigenetics

MBD2

-

Tissue

[71]

miR-376c

Migration

GRB2

Down

Cell lines

[72]

   

(CCT v. N-NT)

  

miR-451

-

-

Down

Tissue

[57]

miR-486

-

-

Down

Tissue

[57]

miR-494

Proliferation, cell cycle

CDK6

-

Cell lines

[73]

miR-495

-

-

Down

Tissue

[57]

   

(Pap. v. N-NT)

  

miR-513

-

-

-

Tissue

[57]

miR-625

-

-

Up

Tissue

[57]

   

(CCT v. N-NT)

  

miR-1926

-

-

-

Tissue

[57]

  1. Unless otherwise stated ‘Direction this work’ refers to the CCT v. D-NT comparison.