Figure 3
Multi-dimensional scaling plots comparing differently graded tumor tissue to matched normal distal tissue and non-CCA normal liver tissue. EdgeR [27] was used to measure distances between the miRNA expression profile of papillary and well differentiated tumor tissue to D-NT and N-NT. When compared to non-CCA normal liver tissue both papillary and well differentiated tumor samples were clearly distinguishable from the control samples. Conversely, when compared to matched D-NT only papillary samples were clearly distinguishable from the control samples.