Figure 6

Effects of bone marrow genotype on B16F10 metastasis.Shb +/− mice received +/+ bone marrow and Shb +/+ mice received +/− bone marrow after transplantation to recipients that had been depleted of their endogenous bone marrow by irradiation. After 3 months when hematopoiesis had been restored, B16F10 tumors were gown subcutaneously, resected and the mice sacrificed when tumor recurrence occurred (average 34 ± 2 days after initial injection of cells in the +/+ recipient group and 36 ± 0 days in the +/− recipient group). Numbers of lung metastases were then scored and given as absolute values (A) or as frequencies of categories (B) where 0 = 0, 1 = 1–5 and 2= >5 metastases. Means ± SEM for 5 mice in each group are given. *indicates p < 0.05 by Students’ t-test.