Table 2 Univariate and multivariate hazard ratios for OS in luminal breast cancer patients (n=211)
From: Altered PPP2R2A and Cyclin D1 expression defines a subgroup of aggressive luminal-like breast cancer
OS | DFS | ||||||||
|---|---|---|---|---|---|---|---|---|---|
Univariate | Multivariate | Univariate | Multivariate | ||||||
Variable | HR (95% CI) | p* | HR (95% CI) | p* | HR (95% CI) | p* | HR (95% CI) | p* | |
PPP2R2A (B55α)-/low Cyclin D1high | Present vs. Absent | 2.71(1.17-6.28) | .020 | 2.09(.89-4.96) | .091 | 2.63(1.26-5.11) | .010 | 2.18(1.02-4.66) | .043 |
HER2 | Positive vs. Negative | 3.37(1.41-8.08) | .006 | 3.94(1.27-7.55) | .013 | 3.02(1.37-6.68) | .006 | 2.92(1.29-6.55) | .010 |
Size | >2cm vs.<2cm | 5.19(1.95-13.85) | .001 | 3.64(1.39-11.18) | .010 | 6.00(2.48-14.51) | <.001 | 4.47(1.91-2.14) | .001 |
Lymph node status# | LNN vs. Positive | 4.13(1.47-11.58) | .007 | 2.49(0.84-7.34) | .099 | 4.08(1.71-9.72) | .002 | 2.36(.99-5.64) | .052 |
Ki-67 index | >14% vs.≥14% | 1.88(.84-4.19) | .12 | - | - | 2.46(1.25-4.83) | .009 | - | - |