Table 1 Discovery cohort - Clinico-pathological data of luminal-like BC patients
From: Altered PPP2R2A and Cyclin D1 expression defines a subgroup of aggressive luminal-like breast cancer
Parameter | Status | Total n=227 | PPP2R2A (B55α)-/lowCyclin D1highn=33 (%) | Others n=194 (%) | p |
|---|---|---|---|---|---|
Age | ≤ 50 | 91 | 14 (15.38) | 77 (84.62) | .767 |
> 50 | 136 | 19 (13.97) | 117 (86.03) | ||
n/a | - | ||||
Size | ≤ 2 cm | 120 | 18 (15.00) | 102 (85.00) | .834 |
> 2 cm | 107 | 15 (14.02) | 92 (85.98) | ||
n/a | - | ||||
Grade | I | 63 | 3 (4.76) | 60 (95.24) | .014 |
II | 108 | 17 (15.74) | 91 (84.26) | ||
III | 55 | 13 (23.64) | 42 (76.36) | ||
n/a | 1 | 1 | |||
Lymph node status | LNN | 105 | 14 (13.33) | 91 (86.67) | .306 |
Node pos. | 103 | 18 (17.48) | 85 (82.52) | ||
n/a | 19 | 1 | 18 | ||
PgR | Positive | 90 | 11 (12.22) | 79 (87.78) | .615* |
Negative | 10 | 2 (20.00) | 8 (80.00) | ||
n/a | 127 | 78 | 51 | ||
HER2 | Positive | 29 | 9 (31.03) | 20 (68.97) | .020* |
Negative | 198 | 24 (12.12) | 174 (87.88) | ||
n/a | - | ||||
KI-67 Index | <14 | 152 | 18 (11.84) | 134 (88.16) | .125 |
≥14 | 60 | 12 (20.00) | 48 (80.00) | ||
n/a | 15 | 3 | 12 | ||
Luminal subtype | A-like | 152 | 17 (11.18) | 135 (88.82) | .041 |
B-like | 75 | 16 (21.33) | 59 (78.67) | ||
n/a | - | ||||
DFS | Num. of events | 41 | 15 | 26 | .002# |
Mean (months) | 91 | 92 | 89 | ||
OS | Num. of events | 30 | 9 | 21 | .001# |
Mean (months) | 95 | 95 | 95 |