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Figure 1 | BMC Cancer

Figure 1

From: Identification of sample-specific regulations using integrative network level analysis

Figure 1

Schematic workflow of DERA. Briefly, the main steps in DERA: 1) Extraction of the prior biological network from public database. 2) Analysis of transcriptomics data separately for each sample to build a gene activity indicator matrix. x ij and y ik represent expression of gene i in tumor j and reference sample k. The value n is the number of reference samples. K is the threshold for the fold change. 3) Overcoming the cross-talk issue between the pathways by using regulatory connections instead of restricting connections within an individual canonical pathway, and 4) Identification core regulations for a group of samples, which are shared and identical at least in T% of samples. Node size is determined by the number of connections.

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