Table 3 Adjusted mean difference in gene expression levels by BMI, overall and by menopausal status
From: Association of high obesity with PAM50 breast cancer intrinsic subtypes and gene expression
| Â | Overalla | Premenopausala | Postmenopausala | ||||||
|---|---|---|---|---|---|---|---|---|---|
ESR1 | Total n | Mean Diff | 95% CI | Total n | Mean Diff | 95% CI | Total n | Mean Diff | 95% CI |
BMI (kg/m 2 ) | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Underweight (<18.5) | 13 | -2.24 | -3.81, -0.67 | 5 | -3.90 | -6.44, -1.36 | 8 | -1.45 | -3.24, 0.33 |
Normal weight (18.5-24.9) | 658 | Ref | Â | 179 | Ref | Â | 427 | Ref | Â |
Overweight (25.0-29.9) | 509 | -0.12 | -0.42, 0.19 | 112 | -0.12 | -0.75, 0.52 | 364 | -0.10 | -0.47, 0.26 |
Mildly Obese (30.0-34.9) | 290 | 0.03 | -0.36, 0.41 | 82 | -0.12 | -0.80, 0.56 | 195 | 0.10 | -0.38, 0.57 |
Highly Obese (≥35.0) | 206 | -0.95 | -1.47, -0.42 | 50 | -0.96 | -1.97, 0.05 | 141 | -0.97 | -1.61, -0.32 |
| Â | Â | Â | Â | p for interaction=0.73 | Â | ||||
| Â | Overall a | Premenopausal a | Postmenopausal a | ||||||
PGR | Total n | Mean Diff | 95% CI | Total n | Mean Diff | 95% CI | Total n | Mean Diff | 95% CI |
BMI (kg/m 2 ) | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Underweight (<18.5) | 13 | -2.31 | -3.98, -0.64 | 5 | -2.02 | -5.23, 1.20 | 8 | -2.46 | -4.29, -0.62 |
Normal weight (18.5-24.9) | 658 | Ref | Â | 179 | Ref | Â | 427 | Ref | Â |
Overweight (25.0-29.9) | 509 | -0.20 | -0.62, 0.22 | 112 | -0.08 | -0.95, 0.79 | 364 | -0.15 | -0.65, 0.35 |
Mildly Obese (30.0-34.9) | 290 | 0.38 | -0.11, 0.88 | 82 | 1.03 | 0.10, 1.96 | 195 | 0.21 | -0.38, 0.81 |
Highly Obese (≥35.0) | 206 | -0.13 | -0.81, 0.55 | 50 | 0.49 | -0.70, 1.68 | 141 | -0.34 | -1.18, 0.50 |
| Â | Â | Â | Â | p for interaction=0.25 | Â | ||||
| Â | Overall a | Premenopausal a | Postmenopausal a | ||||||
ERBB2 | Total n | Mean Diff | 95% CI | Total n | Mean Diff | 95% CI | Total n | Mean Diff | 95% CI |
BMI (kg/m 2 ) | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Underweight (<18.5) | 13 | -0.27 | -1.14, 0.60 | 5 | -0.35 | -2.14, 1.45 | 8 | -0.22 | -1.12, 0.68 |
Normal weight (18.5-24.9) | 658 | Ref | Â | 179 | Ref | Â | 427 | Ref | Â |
Overweight (25.0-29.9) | 509 | -0.01 | -0.16, 0.18 | 112 | 0.26 | -0.14, 0.65 | 364 | -0.04 | -0.24, 0.16 |
Mildly Obese (30.0-34.9) | 290 | -0.08 | -0.28, 0.13 | 82 | 0.10 | -0.32, 0.52 | 195 | -0.09 | -0.34, 0.16 |
Highly Obese (≥35.0) | 206 | -0.04 | -0.32, 0.23 | 50 | -0.16 | -0.67, 0.35 | 141 | 0.03 | -0.32, 0.37 |
| Â | Â | Â | Â | p for interaction=0.68 | Â | ||||
| Â | Overall a | Premenopausal a | Postmenopausal a | ||||||
Proliferation | Total n | Mean Diff | 95% CI | Total n | Mean Diff | 95% CI | Total n | Mean Diff | 95% CI |
BMI (kg/m 2 ) | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Underweight (<18.5) | 13 | 0.17 | -0.65, 1.00 | 5 | 0.33 | -0.42, 1.09 | 8 | 0.02 | -1.18, 1.21 |
Normal weight (18.5-24.9) | 658 | Ref | Â | 179 | Ref | Â | 427 | Ref | Â |
Overweight (25.0-29.9) | 509 | 0.18 | -0.01, 0.36 | 112 | 0.01 | -0.32, 0.34 | 364 | 0.18 | -0.04, 0.40 |
Mildly Obese (30.0-34.9) | 290 | 0.16 | -0.06, 0.38 | 82 | -0.10 | -0.47, 0.28 | 195 | 0.17 | -0.09, 0.42 |
Highly Obese (≥35.0) | 206 | 0.44 | 0.18, 0.71 | 50 | -0.09 | -0.53, 0.36 | 141 | 0.54 | 0.21, 0.86 |
| Â | Â | Â | Â | p for interaction=0.06 | Â | ||||