Association of high obesity with PAM50 breast cancer intrinsic subtypes and gene expression

BMC Cancer

Table 2 PAM50 gene expression levels by BMI around breast cancer diagnosis and menopausal status, LACE and Pathways cohorts

	Underweight	Normal weight	Overweight	Mildly Obese	Highly Obese	p value^a
	<18.5 kg/m²	18.5-24.9 kg/m²	25.0-29.9 kg/m²	30-34.9 kg/m²	≥35.0 kg/m²
	mean	mean	mean	mean	mean
	n=13	n=658	n=509	n=290	n=206
Overall (n=1,676)
ESR1	10.95	12.31	12.32	12.43	11.54	0.03
PGR	6.73	7.98	7.82	8.33	7.76	0.86
ERBB2	13.18	13.84	13.78	13.71	13.68	0.08
Proliferation	9.07	8.64	8.75	8.79	9.12	0.02
Premenopausal (n=428)
ESR1	10.61	11.93	11.78	11.70	10.78	0.01
PGR	7.57	7.74	7.51	8.44	7.64	0.79
ERBB2	12.84	13.76	13.96	13.87	13.42	0.32
Proliferation	9.62	9.16	9.17	9.13	9.15	0.85
Postmenopausal (n=1,135)
ESR1	11.37	12.50	12.54	12.73	11.80	0.17
PGR	5.71	8.01	7.96	8.31	7.77	0.76
ERBB2	13.59	13.87	13.73	13.67	13.76	0.15
Proliferation	8.40	8.49	8.60	8.66	9.09	0.01

NOTE: Raw values are re-scaled by adding a constant of 10 units to interpret and preserve rank order.
^a P values from generalized linear model (GLM) for gene expression.

ISSN: 1471-2407