TLR3 expression correlates with apoptosis, proliferation and angiogenesis in hepatocellular carcinoma and predicts prognosis

Table 7 Correlation between the expression of TLR3 signaling-pathway proteins with those of Ki67, cyclin D1, MMP-2, CD34 and analysis of EPCs in HCC tissues

Item	N	TLR3			Spearman		TRIF			Spearman		IRF3			Spearman		NF-κB			Spearman
		expression			analysis		expression			analysis		expression			analysis		expression			analysis
		−	+	++	γ	P	−	+	++	γ	P	−	+	++	γ	P	−	+	++	γ	P
Ki-67					−0.276	0.011				−0.215	0.048				−0.281	0.009				−0.265	0.014
−	33	12	4	17			8	9	16			10	12	11			9	12	12
+	36	12	15	19			12	7	17			19	9	8			12	14	10
++	16	11	3	2			6	9	1			11	3	2			10	5	1
CyclinD1					−0.269	0.013				−0.219	0.044				−0.292	0.007				−0.262	0.016
−	36	11	7	18			10	6	20			11	13	12			12	11	13
+	28	12	10	6			9	11	8			17	5	6			11	12	5
++	21	12	5	4			7	8	6			12	6	3			8	8	5
MMP-2					−0.378	0.000				−0.294	0.006				−0.196	0.073				−0.248	0.022
−	37	10	9	18			8	8	21			15	9	13			11	12	14
+	25	9	8	8			9	7	9			10	12	3			8	10	7
++	23	16	5	2			9	10	4			15	3	5			12	9	2
MVD					−0.583	0.000				−0.560	0.000				−0.527	0.000				−0.484	0.000
≤120	23	3	4	16			1	4	18			16	7	2			2	8	13
121–240	37	11	17	9			9	14	14			15	9	13			12	19	6
>240	25	21	1	3			16	7	2			22	2	1			17	4	4
EPCs count					−0.544	0.000				−0.458	0.000				−0.277	0.010				−0.345	0.001
≤5	54	13	18	23			10	14	30			21	17	16			14	23	17
6 - 10	22	14	4	4			8	11	3			10	7	5			10	7	5
>10	9	8	0	1			8	0	1			9	0	0			7	1	1

ISSN: 1471-2407