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Table 4 Cisplatin regulates the expression of tumor suppressors and oncogenes

From: Role of the splicing factor SRSF4 in cisplatin-induced modifications of pre-mRNA splicing and apoptosis

Name

Fold change

q-value

Tumor suppressors

SERPINB5

128.0

0.000

TP53INP1

9.2

0.000

SULF1

−55.7

0.001

ERBB4

−78.8

0.001

BUB1B

−21.1

0.002

MAFB

10.6

0.004

STARD13

−22.6

0.004

HIPK2

−13.0

0.004

SASH1

−11.3

0.009

MTUS1

−6.1

0.027

BRCA1

−7.0

0.031

ST7

−27.9

0.033

RB1

−4.3

0.035

IRF1

4.9

0.040

TP63

−34.3

0.042

FANCD2

−4.6

0.047

Oncogenes

NCOA1

−13.0

0.001

MAFB

10.6

0.004

FOS

8.6

0.004

JAK2

−11.3

0.005

PRKCA

−12.1

0.006

GMPS

−5.7

0.011

MYB

−21.1

0.013

MLLT3

−68.6

0.015

AKAP13

−6.1

0.019

JUN

4.6

0.028

MCF2L

−6.5

0.035

  1. The fold change and p-value are indicated. The list of the genes regulated by cisplatin was compared to lists of oncogenes (http://www.uniprot.org/uniprot/?query=keyword:KW-0656) and tumours suppressors (http://www.uniprot.org/uniprot/?query=keyword:KW-0043).