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Table 3 Predictive factors of AA treatment duration

From: Abiraterone acetate in patients with metastatic castration-resistant prostate cancer: long term outcome of the Temporary Authorization for Use programme in France

 

Univariate analysis

 

Multivariate analysis

 
 

OR

p

OR

p

Age

<60 vs

1

0.107

  

> = 60

0.57 95% CI [0.29-1.13]

Gleason score

4-6

1

   

7

1.24 95% CI [0.45-3.39]

0.68

8-10

1.16 95% CI [0.44-3.05]

0.76

Duration of CT before AA treatment

<=4 months

1

   

]4-6]

0.99 95% [0.42-2.31]

0.98

[6-9]

2.00 95% [0.81-4.98]

0.13

>9

1.17 95% [0.53-2.59]

0.70

PSA baseline before CT

Continuous variable

0.99 95% [0.99-1.00]

0.10

  

PSA baseline before AA

Continuous variable

1.00 95% [0.99-1.00]

0.67

  

Sites of metastasis

Bone or visceral alone vs Multiple

1

0.17

1

 

0.65 95% CI [0.36-1.19]

 

0.71 95% [0.35-1.44]

0.34

Number of CT lines

1

1

   

2

1.02 95% [0.53-1.99]

0.94

3

1.23 95% [0.33-4.56]

0.75

4-5

0.26 95% [0.02-4.34]

0.35

PSA variation at 3 months

Decrease

1

<0.0001

1

 

Increase

0.06 95% [0.02-0.19]

 

0.13 95% [0.06-0.31]

<0.0001