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Table 4 Association between breast density/parenchymal pattern and breast cancer

From: Inter-observer agreement according to three methods of evaluating mammographic density and parenchymal pattern in a case control study: impact on relative risk of breast cancer

  Cases (n) Controls (n) Cancer ratio OR (95% Cl)* P
BI-RADS
Reader 1
     
D1 29 103 22.0 1.00 (reference) -
D2 25 72 25.8 1.25 (0.67-2.31) 0.482 (NS)
D3 42 62 40.4 2.47 (1.39-4.39) 0.002
D4 26 25 51.0 3.87 (1.91-7.85) <0.001
D1+D2 54 175 23.6 1.00 (reference) -
D3+D4 68 87 43.9 2.58 (1.64-4.04) <0.001
Reader 2      
D1 32 114 21.9 1.00 (reference) -
D2 39 90 30.2 1.57 (0.91-2.72) 0.106 (NS)
D3 38 44 46.3 3.17 (1.74-5.76) <0.001
D4 13 14 48.1 3.45 (1.45-8.25) 0.005
D1+D2 71 204 25.8 1.00 (reference) -
D3+D4 51 58 46.8 2.56 (1.59-4.10) <0.001
Tabár
Reader 1
     
PI 34 92 27.0 1.56 (0.83-2.92) 0.168 (NS)
PII 20 85 19.0 1.00 (reference) -
PIII 5 9 35.7 2.36 (0.71-7.81) 0.160 (NS)
PIV 59 60 49.6 4.14 (2.26-7.61) <0.001
PV 4 16 20.0 1.04 (0.31-3.48) 0.955 (NS)
PI+PII+PIII 59 186 24.1 1.00 (reference) -
PIV+PV 63 76 45.3 2.61 (1.67-4.07) <0.001
Reader 2      
PI 49 111 30.6 3.31 (1.58-6.95) 0.002
PII 10 75 11.8 1 (reference) -
PIII 6 8 42.9 5.62 (1.61-19.62) 0.007
PIV 43 42 50.6 7.69 (3.49-16.91) <0.001
PV 14 26 35.0 4.05 (1.59-10.30) 0.003
PI+PII+PIII 65 194 25.1 1.00 (reference) -
PIV+PV 57 68 45.6 2.51 (1.59-3.97) <0.001
Percentage density
Reader 1**
     
Q1 40 122 24.7 1 (reference) -
Q2 36 76 32.1 1.45 (0.85-2.49) 0.173 (NS)
Q3 32 44 42.1 2.24 (1.24-4.02) 0.007
Q4 14 20 41.2 2.17 (0.98-4.81) 0.056 (NS)
Q1+Q2 76 198 27.7 1.00 (reference) -
Q3+Q4 46 64 41.8 1.87 (1.17-3.00) 0.009
Reader 2**      
Q1 28 95 22.8 1 (reference) -
Q2 45 99 31.3 1.55 (0.89-2.68) 0.120 (NS)
Q3 33 56 37.1 2.03 (1.10-3.74) 0.023
Q4 16 12 57.1 4.65 (1.93-11.16) 0.001
Q1+Q2 73 194 27.3 1.00 (reference) -
Q3+Q4 49 68 41.9 1.92 (1.21-3.07) 0.006
  1. Relative risk estimates in terms of ORs from assessment by three subjective scoring methods by Reader 1 and 2.
  2. *Adjusted for age.
  3. **PMD grouped in quartiles with cut offs within density range: R1 (%): Q1) 0.99-17.89, Q2) 17.90-34.80, Q3) 34.81-51.71, Q4) 51.72-68.62; R2 (%): Q1) 1.51-17.66, Q2) 17.67-33.81, Q3) 33.82-49.96, Q4) 49.97-66.12.