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Figure 1 | BMC Cancer

Figure 1

From: Treatment of advanced gastrointestinal tumors with genetically modified autologous mesenchymal stromal cells (TREAT-ME1): study protocol of a phase I/II clinical trial

Figure 1

Configuration of the retroviral vector pEMTAR-bi.RANTES.tk used to transfect primary MSCs to generate the IMP MSC_apceth_101. MPSV: myeloproliferative sarcoma virus-promoter γ-retroviral R-region, U5: γ-retroviral U5-region, Ψ: Packaging signal, pRANTES: human RANTES promoter, HSV-TK: Herpes simples Thymidine kinase, HA: Hemagglutinin epitope, pPGK: human Phosphoglycerate Kinase promoter, Puro: Puromycin resistance gene, wPRE: woodchuck Hepatitis post-transcriptional regulatory element, dU3: deleted γ-retroviral U3-region, SIN: self-inactivating.

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