TY - JOUR AU - Niess, Hanno AU - von Einem, Jobst C. AU - Thomas, Michael N. AU - Michl, Marlies AU - Angele, Martin K. AU - Huss, Ralf AU - Günther, Christine AU - Nelson, Peter J. AU - Bruns, Christiane J. AU - Heinemann, Volker PY - 2015 DA - 2015/04/08 TI - Treatment of advanced gastrointestinal tumors with genetically modified autologous mesenchymal stromal cells (TREAT-ME1): study protocol of a phase I/II clinical trial JO - BMC Cancer SP - 237 VL - 15 IS - 1 AB - Adenocarcinoma originating from the digestive system is a major contributor to cancer-related deaths worldwide. Tumor recurrence, advanced local growth and metastasis are key factors that frequently prevent these tumors from curative surgical treatment. Preclinical research has demonstrated that the dependency of these tumors on supporting mesenchymal stroma results in susceptibility to cell-based therapies targeting this stroma. SN - 1471-2407 UR - https://doi.org/10.1186/s12885-015-1241-x DO - 10.1186/s12885-015-1241-x ID - Niess2015 ER -