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Figure 1 | BMC Cancer

Figure 1

From: Chemoresistance is associated with increased cytoprotective autophagy and diminished apoptosis in bladder cancer cells treated with the BH3 mimetic (−)-Gossypol (AT-101)

Figure 1

Establishment of cellular resistance models. Bladder cancer cell lines 5637 and RT4 were adapted to growth in the chemotherapeutic presence of 20 ng/ml gemcitabine (rGEMCI20) or 1000 ng/ml Cisplatin (rCDDP1000). 50% inhibiting concentration (IC50) Values are mean from three independant experiments ± SD and are shown in A. Chemo-sensitive (5637, RT4) and chemo-resistant cells (5637rGEMCI20, 5637rCDDP1000, RT4rGEMCI20, RT4rCDDP1000) were treated with 3 μM Staurosporin (STS), an inducer of apoptotic cell death, for 6 h and cell viability was measured by the MTT Assay.*, P < 0.05 compared with the parental cell line (B).

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