Table 1 Cox proportional hazards analyses of the association between PFS and OS and the classification of the clinical cohorts for doxorubcin REGS developed using HBCCL or CGP cell line panels
HBCCL | CGP | |||||
|---|---|---|---|---|---|---|
N | HR (95% CI) | P-value | N | HR (95% CI) | P-value | |
REGS classifier (univariate) | ||||||
IDRC (PFS) | 470 | 2.58 (1.72,3.86) | 4.37E-06 | 470 | 1.54 (1.07,2.22) | 0.0211 |
LLMPP (PFS) | 220 | 2.28 (1.10,4.73) | 0.0269 | 220 | 1.70 (0.89,3.22) | 0.105 |
MDFCI (OS) | 67 | 4.56 (1.29,16.19) | 0.0188 | 67 | 0.93 (0.28,3.04) | 0.899 |
REGS classifier (adjusted for IPI) | ||||||
IDRC (PFS) | 424 | 2.52 (1.64,3.87) | 2.65E-05 | 424 | 1.46 (0.99,2.16) | 0.0562 |
LLMPP (PFS) | 180 | 2.52 (1.13,5.64) | 0.0237 | 180 | 1.37 (0.68,2.74) | 0.375 |
MDFCI (OS) | 63 | 4.05 (1.13,14.51) | 0.0318 | 63 | 0.84 (0.25,2.76) | 0.769 |
REGS predictor (univariate) | ||||||
IDRC (PFS) | 470 | 1.11 (1.04,1.17) | 0.000572 | 470 | 1.07 (1.01,1.13) | 0.0131 |
LLMPP (PFS) | 220 | 1.10 (1.00,1.20) | 0.0438 | 220 | 1.09 (0.99,1.19) | 0.0794 |
MDFCI (OS) | 67 | 1.32 (1.14,1.54) | 0.000318 | 67 | 0.96 (0.83,1.12) | 0.63 |
REGS predictor (adjusted for IPI) | ||||||
IDRC (PFS) | 424 | 1.09 (1.03,1.16) | 0.00595 | 424 | 1.05 (1.00,1.11) | 0.0733 |
LLMPP (PFS) | 180 | 1.11 (1.00,1.23) | 0.0433 | 180 | 1.04 (0.94,1.15) | 0.467 |
MDFCI (OS) | 63 | 1.34 (1.15,1.57) | 0.000237 | 63 | 0.95 (0.83,1.07) | 0.387 |