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Table 1 Cox proportional hazards analyses of the association between PFS and OS and the classification of the clinical cohorts for doxorubcin REGS developed using HBCCL or CGP cell line panels

From: Predicting response to multidrug regimens in cancer patients using cell line experiments and regularised regression models

  HBCCL CGP
  N HR (95% CI) P-value N HR (95% CI) P-value
REGS classifier (univariate)
IDRC (PFS) 470 2.58 (1.72,3.86) 4.37E-06 470 1.54 (1.07,2.22) 0.0211
LLMPP (PFS) 220 2.28 (1.10,4.73) 0.0269 220 1.70 (0.89,3.22) 0.105
MDFCI (OS) 67 4.56 (1.29,16.19) 0.0188 67 0.93 (0.28,3.04) 0.899
REGS classifier (adjusted for IPI)
IDRC (PFS) 424 2.52 (1.64,3.87) 2.65E-05 424 1.46 (0.99,2.16) 0.0562
LLMPP (PFS) 180 2.52 (1.13,5.64) 0.0237 180 1.37 (0.68,2.74) 0.375
MDFCI (OS) 63 4.05 (1.13,14.51) 0.0318 63 0.84 (0.25,2.76) 0.769
REGS predictor (univariate)
IDRC (PFS) 470 1.11 (1.04,1.17) 0.000572 470 1.07 (1.01,1.13) 0.0131
LLMPP (PFS) 220 1.10 (1.00,1.20) 0.0438 220 1.09 (0.99,1.19) 0.0794
MDFCI (OS) 67 1.32 (1.14,1.54) 0.000318 67 0.96 (0.83,1.12) 0.63
REGS predictor (adjusted for IPI)
IDRC (PFS) 424 1.09 (1.03,1.16) 0.00595 424 1.05 (1.00,1.11) 0.0733
LLMPP (PFS) 180 1.11 (1.00,1.23) 0.0433 180 1.04 (0.94,1.15) 0.467
MDFCI (OS) 63 1.34 (1.15,1.57) 0.000237 63 0.95 (0.83,1.07) 0.387
  1. In the multivariate analysis the Cox proportional hazards regression is adjusted for IPI. The estimated HR’s compare patients classified as resistant to patients classified as sensitive.