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Table 2 Demographics and clinical characteristics of AML patients according to ASCs ratio

From: Direct confirmation of quiescence of CD34+CD38- leukemia stem cell populations using single cell culture, their molecular signature and clinicopathological implications

  

Low ASC ratio (<0.1) group

High ASC ratio (>0.1) group

p-value

N

 

27

33

 

Male/Female

 

14/13

14/19

0.466

Age, years

Min

15

16

0.471

 

Max

81

82

 
 

Median (SD)

49 (3.2)

58 (3.2)

 

FAB classifications, N (%)

  

0.724

 

M0

2 (7.4)

1 (3.0)

 
 

M1

3 (11.1)

2 (6.1)

 
 

M2

15 (55.6)

19 (57.6)

 
 

M4

6 (22.2)

7 (21.2)

 
 

M5

1 (3.7)

2 (6.1)

 
 

M6

0 (0.0)

2 (6.1)

 

Cytogenetics, N (%)*

   

0.621

 

Favorable

9 (33.3)

9 (27.3)

 
 

Intermediate

16 (59.3)

19 (57.6)

 
 

Unfavorable

2 (7.4)

5 (15.2)

 

CD34% groups, N (%)

   

0.031

 

%CD34+ <5

2 (7.4)

7 (21.2)

 
 

5 ≤ %CD34+ <20

3 (11.1)

10 (30.3)

 
 

20 ≤ %CD34+

22 (81.5)

16 (48.5)

 

WBC (*1000/uL)

Median

30.1

25.2

0.379

PLT (*1000/uL)

Median

37

44

0.698

Hemoglobin (g/dL)

Median

8.5

8.2

0.871

BM blast, %

Median

73

60

0.078

Expired case, N (%)

 

9 (33.3)

16 (48.5)

0.236

Relapse case, N (%)

 

14 (51.9)

17 (51.5)

0.979

Median overall survival, months

 

12

7

0.211

Median relapse free survival, months

 

7

6

0.442

  1. ASCs ratio, the number of AML stem cell per the number of CD34+ cells; N, number; PLT, platelet; BM, bone marrow.
  2. *Cytogenetic groups were divided according to the NCCN guideline [44].