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Table 1 Combination index (CI) values of topotecan and PF477736 co-treatment in ovarian cancer cells

From: Topotecan synergizes with CHEK1 (CHK1) inhibitor to induce apoptosis in ovarian cancer cells

Total Dose (uM) Ovcar5 Ovcar3 Ovcar8 OV90 PEO1 PEO4
TPT + PF Fa CI Fa CI Fa CI Fa CI Fa CI Fa CI
0.25 + 0.5 0.84 1.4 0.86 0.9 0.87 1.6 0.71 1.2 0.85 1.9 0.64 1.3
0.125 + 0.25 0.79 0.9 0.83 0.5 0.83 0.9 0.67 0.9 0.84 1.1 0.60 0.8
0.063 + 0.125 0.70 0.6 0.73 0.5 0.74 0.5 0.60 0.7 0.81 0.7 0.54 0.5
0.032 + 0.063 0.47 0.7 0.76 0.2 0.68 0.3 0.54 0.5 0.77 0.5 0.42 0.4
  1. Fa (Fraction affected) was calculated from XTT assays and Fa value of greater than 0.8 is cytotoxic considering the detectable limit of XTT assay. Cellular killing was examined under light microscope before measuring the viability. Synergistic CI values with Fa values are shown in bold.