Table 1 Combination index (CI) values of topotecan and PF477736 co-treatment in ovarian cancer cells
From: Topotecan synergizes with CHEK1 (CHK1) inhibitor to induce apoptosis in ovarian cancer cells
Total Dose (uM) | Ovcar5 | Ovcar3 | Ovcar8 | OV90 | PEO1 | PEO4 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
TPT + PF | Fa | CI | Fa | CI | Fa | CI | Fa | CI | Fa | CI | Fa | CI |
0.25 + 0.5 | 0.84 | 1.4 | 0.86 | 0.9 | 0.87 | 1.6 | 0.71 | 1.2 | 0.85 | 1.9 | 0.64 | 1.3 |
0.125 + 0.25 | 0.79 | 0.9 | 0.83 | 0.5 | 0.83 | 0.9 | 0.67 | 0.9 | 0.84 | 1.1 | 0.60 | 0.8 |
0.063 + 0.125 | 0.70 | 0.6 | 0.73 | 0.5 | 0.74 | 0.5 | 0.60 | 0.7 | 0.81 | 0.7 | 0.54 | 0.5 |
0.032 + 0.063 | 0.47 | 0.7 | 0.76 | 0.2 | 0.68 | 0.3 | 0.54 | 0.5 | 0.77 | 0.5 | 0.42 | 0.4 |