Figure 2
From: NPC1L1 knockout protects against colitis-associated tumorigenesis in mice
Pathological changes.(A) Colons were excised 10 weeks after AOM injection (left) and were longitudinally opened (right). (B) Colons were excised 20 weeks after AOM injection and were stained with H&E. (C) Squamous metaplasia, adenoma, high grade intraepithelial neoplasia and adenocarcinoma were found in WT group and NPC1L1−/− group. (Scale bars represent 400 μm.) (D) NPC1L1−/− mice had a lower ratio of malignant tumor/tumor than WT mice. *p < 0.05.