ROC curve of MDM2 and Ki-67 in cStageIII. The receiver operating characteristic (ROC) curve analysis of MDM2 positivity in cStageIII patients identified a cut-off for the Failure group at 9.05% that provided 90% sensitivity and 60% specificity, with a positive predictive value (PPV) of 87.1% and a negative predictive value (NPV) of 66.7%. The area under the curve (AUC) was 0.76 (A). The ROC curve analysis of Ki-67 positivity in cStageIII identified a cut-off for the CR group at 33.7% that provided 70% sensitivity and 70% specificity, with a PPV of 43.8% and a NPV of 87.5%. The AUC was 0.68 (B).