Figure 4From: Oridonin stabilizes retinoic acid receptor alpha through ROS-activated NF-κB signalingNF-κB inhibitor blocks oridonin-induced RARαstability. After pretreatment with and without PD98059, SB203580, SP600125 (A), Bay 11–7082 (B, C), or NAC (D) for 1 h, NB4 cells or primary AML cells were treated with 10 μM oridonin for 12 h, followed by western blot analysis of proteins as indicated. All experiments were repeated three times and gave consistent results.Back to article page