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Table 4 Multivariate analyses of CA7 expression and disease-specific survival for patients with early or advanced stage tumors in the training and validation cohorts

From: Prognostic value of carbonic anhydrase VII expression in colorectal carcinoma

Variables Categories Early stage Advanced stage
   HR 95% CI P valueb HR 95% CI P valueb
Training Cohort
Age (years) ≥60 / <60 4.062 1.592-10.365 0.003 2.353 1.282-4.319 0.006
Sex Male / female       
Tumor location Colon / rectum       
Tumor size (cm) ≥5 / <5       
Differentiation grade Poor / well + moderate     2.389 1.419-4.023 0.001
CA7 expressiona Low / high 2.232 1.220-4.082 0.009 2.809 1.524-5.181 0.001
Validation Cohort
Age (years) ≥60 / <60     2.374 1.176-4.794 0.016
Sex Male / female       
Tumor location Colon / rectum       
Tumor size (cm) ≥5 / <5       
Differentiation grade Poor / well + moderate     2.637 1.414-4.920 0.002
CA7 expressiona Low / high 3.165 1.326-7.519 0.009    
  1. Abbreviations:HR hazard ratio, 95% CI 95% confidence interval.
  2. aFor CA7, median values were used as the cut-off point for definition of subgroups (low expression and high expression groups).
  3. bBold type indicates statistical significance.
  4. Multivariate models were adjusted for age, sex, tumor location, tumor size and differentiation grade.