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Table 4 Multivariate analyses of CA7 expression and disease-specific survival for patients with early or advanced stage tumors in the training and validation cohorts

From: Prognostic value of carbonic anhydrase VII expression in colorectal carcinoma

Variables

Categories

Early stage

Advanced stage

  

HR

95% CI

P valueb

HR

95% CI

P valueb

Training Cohort

Age (years)

≥60 / <60

4.062

1.592-10.365

0.003

2.353

1.282-4.319

0.006

Sex

Male / female

      

Tumor location

Colon / rectum

      

Tumor size (cm)

≥5 / <5

      

Differentiation grade

Poor / well + moderate

   

2.389

1.419-4.023

0.001

CA7 expressiona

Low / high

2.232

1.220-4.082

0.009

2.809

1.524-5.181

0.001

Validation Cohort

Age (years)

≥60 / <60

   

2.374

1.176-4.794

0.016

Sex

Male / female

      

Tumor location

Colon / rectum

      

Tumor size (cm)

≥5 / <5

      

Differentiation grade

Poor / well + moderate

   

2.637

1.414-4.920

0.002

CA7 expressiona

Low / high

3.165

1.326-7.519

0.009

   
  1. Abbreviations:HR hazard ratio, 95% CI 95% confidence interval.
  2. aFor CA7, median values were used as the cut-off point for definition of subgroups (low expression and high expression groups).
  3. bBold type indicates statistical significance.
  4. Multivariate models were adjusted for age, sex, tumor location, tumor size and differentiation grade.