From: Prognostic value of carbonic anhydrase VII expression in colorectal carcinoma
Variables | Categories | Early stage | Advanced stage | ||||
---|---|---|---|---|---|---|---|
 |  | HR | 95% CI | P valueb | HR | 95% CI | P valueb |
Training Cohort | |||||||
Age (years) | ≥60 / <60 | 4.062 | 1.592-10.365 | 0.003 | 2.353 | 1.282-4.319 | 0.006 |
Sex | Male / female | Â | Â | Â | Â | Â | Â |
Tumor location | Colon / rectum | Â | Â | Â | Â | Â | Â |
Tumor size (cm) | ≥5 / <5 |  |  |  |  |  |  |
Differentiation grade | Poor / well + moderate |  |  |  | 2.389 | 1.419-4.023 | 0.001 |
CA7 expressiona | Low / high | 2.232 | 1.220-4.082 | 0.009 | 2.809 | 1.524-5.181 | 0.001 |
Validation Cohort | |||||||
Age (years) | ≥60 / <60 |  |  |  | 2.374 | 1.176-4.794 | 0.016 |
Sex | Male / female | Â | Â | Â | Â | Â | Â |
Tumor location | Colon / rectum | Â | Â | Â | Â | Â | Â |
Tumor size (cm) | ≥5 / <5 |  |  |  |  |  |  |
Differentiation grade | Poor / well + moderate |  |  |  | 2.637 | 1.414-4.920 | 0.002 |
CA7 expressiona | Low / high | 3.165 | 1.326-7.519 | 0.009 | Â | Â | Â |