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Table 2 Association between CA7 expression and clinicopathologic characteristics of CRC patients in the training and validation cohorts

From: Prognostic value of carbonic anhydrase VII expression in colorectal carcinoma

 

Training cohort (n = 228)

Validation cohort (n = 151)

Characteristics

CA7 expression

P valuea

CA7 expression

P valuea

Low (%)

High (%)

Low (%)

High (%)

(n = 116)

(n = 112)

(n = 89)

(n = 62)

Age (years)

    

0.267

    

0.622

  <60

40

(34.5)

31

(27.7)

 

24

(27.0)

19

(30.6)

 

  ≥60

76

(65.5)

81

(72.3)

 

65

(73.0)

43

(69.4)

 

Sex

    

0.720

    

0.490

  Female

47

(40.5)

48

(42.9)

 

38

(42.7)

23

(37.1)

 

  Male

69

(59.5)

64

(57.1)

 

51

(57.3)

39

(62.9)

 

Tumor location

    

0.224

    

0.806

  Rectum

90

(77.6)

79

(70.5)

 

47

(52.8)

34

(54.8)

 

  Colon

26

(22.4)

33

(29.5)

 

42

(47.2)

28

(45.2)

 

Differentiation grade

    

0.006

    

0.046

  Well/Moderate

78

(67.2)

93

(83.0)

 

62

(69.7)

52

(83.9)

 

  Poor

38

(32.8)

19

(17.0)

 

27

(30.3)

10

(16.1)

 

Tumor size (cm)

    

0.448

    

0.586

  <5

44

(37.9)

48

(42.9)

 

32

(36.0)

25

(40.3)

 

  ≥5

72

(62.1)

64

(57.1)

 

57

(64.0)

37

(59.7)

 

Local invasion

    

0.141

    

0.064

  T1-T2

18

(15.5)

26

(23.2)

 

5

(5.6)

9

(14.5)

 

  T3-T4

98

(84.5)

86

(76.8)

 

84

(94.4)

53

(85.5)

 

Lymph node metastasis

   

0.003

    

0.003

  N0

56

(48.3)

76

(67.9)

 

41

(46.1)

43

(69.4)

 

  N1

36

(31.0)

28

(25.0)

 

31

(34.8)

17

(27.4)

 

  N2

24

(20.7)

8

(7.1)

 

17

(19.1)

2

(3.2)

 

TNM stage

    

0.008

    

0.003

  I

13

(11.2)

23

(20.5)

 

2

(2.2)

8

(12.9)

 

  II

43

(37.1)

53

(47.3)

 

39

(43.9)

35

(56.5)

 

  III

60

(51.7)

36

(32.2)

 

48

(53.9)

19

(30.6)

 

Death

    

<0.001

    

<0.001

  No

47

(40.5)

77

(68.8)

 

37

(41.6)

45

(72.6)

 

  Yes

69

(59.5)

35

(31.2)

 

52

(58.4)

17

(27.4)

 
  1. aPearson chi-square test or Fisher exact test was used for comparison between subgroups. Bold type indicates statistical significance.