From: Prognostic value of carbonic anhydrase VII expression in colorectal carcinoma
Training cohort (n = 228) | Validation cohort (n = 151) | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Characteristics | CA7 expression | P valuea | CA7 expression | P valuea | ||||||
Low (%) | High (%) | Low (%) | High (%) | |||||||
(n = 116) | (n = 112) | (n = 89) | (n = 62) | |||||||
Age (years) | 0.267 | 0.622 | ||||||||
<60 | 40 | (34.5) | 31 | (27.7) | 24 | (27.0) | 19 | (30.6) | ||
≥60 | 76 | (65.5) | 81 | (72.3) | 65 | (73.0) | 43 | (69.4) | ||
Sex | 0.720 | 0.490 | ||||||||
Female | 47 | (40.5) | 48 | (42.9) | 38 | (42.7) | 23 | (37.1) | ||
Male | 69 | (59.5) | 64 | (57.1) | 51 | (57.3) | 39 | (62.9) | ||
Tumor location | 0.224 | 0.806 | ||||||||
Rectum | 90 | (77.6) | 79 | (70.5) | 47 | (52.8) | 34 | (54.8) | ||
Colon | 26 | (22.4) | 33 | (29.5) | 42 | (47.2) | 28 | (45.2) | ||
Differentiation grade | 0.006 | 0.046 | ||||||||
Well/Moderate | 78 | (67.2) | 93 | (83.0) | 62 | (69.7) | 52 | (83.9) | ||
Poor | 38 | (32.8) | 19 | (17.0) | 27 | (30.3) | 10 | (16.1) | ||
Tumor size (cm) | 0.448 | 0.586 | ||||||||
<5 | 44 | (37.9) | 48 | (42.9) | 32 | (36.0) | 25 | (40.3) | ||
≥5 | 72 | (62.1) | 64 | (57.1) | 57 | (64.0) | 37 | (59.7) | ||
Local invasion | 0.141 | 0.064 | ||||||||
T1-T2 | 18 | (15.5) | 26 | (23.2) | 5 | (5.6) | 9 | (14.5) | ||
T3-T4 | 98 | (84.5) | 86 | (76.8) | 84 | (94.4) | 53 | (85.5) | ||
Lymph node metastasis | 0.003 | 0.003 | ||||||||
N0 | 56 | (48.3) | 76 | (67.9) | 41 | (46.1) | 43 | (69.4) | ||
N1 | 36 | (31.0) | 28 | (25.0) | 31 | (34.8) | 17 | (27.4) | ||
N2 | 24 | (20.7) | 8 | (7.1) | 17 | (19.1) | 2 | (3.2) | ||
TNM stage | 0.008 | 0.003 | ||||||||
I | 13 | (11.2) | 23 | (20.5) | 2 | (2.2) | 8 | (12.9) | ||
II | 43 | (37.1) | 53 | (47.3) | 39 | (43.9) | 35 | (56.5) | ||
III | 60 | (51.7) | 36 | (32.2) | 48 | (53.9) | 19 | (30.6) | ||
Death | <0.001 | <0.001 | ||||||||
No | 47 | (40.5) | 77 | (68.8) | 37 | (41.6) | 45 | (72.6) | ||
Yes | 69 | (59.5) | 35 | (31.2) | 52 | (58.4) | 17 | (27.4) |