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Table 2 Association between CA7 expression and clinicopathologic characteristics of CRC patients in the training and validation cohorts

From: Prognostic value of carbonic anhydrase VII expression in colorectal carcinoma

  Training cohort (n = 228) Validation cohort (n = 151)
Characteristics CA7 expression P valuea CA7 expression P valuea
Low (%) High (%) Low (%) High (%)
(n = 116) (n = 112) (n = 89) (n = 62)
Age (years)      0.267      0.622
  <60 40 (34.5) 31 (27.7)   24 (27.0) 19 (30.6)  
  ≥60 76 (65.5) 81 (72.3)   65 (73.0) 43 (69.4)  
Sex      0.720      0.490
  Female 47 (40.5) 48 (42.9)   38 (42.7) 23 (37.1)  
  Male 69 (59.5) 64 (57.1)   51 (57.3) 39 (62.9)  
Tumor location      0.224      0.806
  Rectum 90 (77.6) 79 (70.5)   47 (52.8) 34 (54.8)  
  Colon 26 (22.4) 33 (29.5)   42 (47.2) 28 (45.2)  
Differentiation grade      0.006      0.046
  Well/Moderate 78 (67.2) 93 (83.0)   62 (69.7) 52 (83.9)  
  Poor 38 (32.8) 19 (17.0)   27 (30.3) 10 (16.1)  
Tumor size (cm)      0.448      0.586
  <5 44 (37.9) 48 (42.9)   32 (36.0) 25 (40.3)  
  ≥5 72 (62.1) 64 (57.1)   57 (64.0) 37 (59.7)  
Local invasion      0.141      0.064
  T1-T2 18 (15.5) 26 (23.2)   5 (5.6) 9 (14.5)  
  T3-T4 98 (84.5) 86 (76.8)   84 (94.4) 53 (85.5)  
Lymph node metastasis     0.003      0.003
  N0 56 (48.3) 76 (67.9)   41 (46.1) 43 (69.4)  
  N1 36 (31.0) 28 (25.0)   31 (34.8) 17 (27.4)  
  N2 24 (20.7) 8 (7.1)   17 (19.1) 2 (3.2)  
TNM stage      0.008      0.003
  I 13 (11.2) 23 (20.5)   2 (2.2) 8 (12.9)  
  II 43 (37.1) 53 (47.3)   39 (43.9) 35 (56.5)  
  III 60 (51.7) 36 (32.2)   48 (53.9) 19 (30.6)  
Death      <0.001      <0.001
  No 47 (40.5) 77 (68.8)   37 (41.6) 45 (72.6)  
  Yes 69 (59.5) 35 (31.2)   52 (58.4) 17 (27.4)  
  1. aPearson chi-square test or Fisher exact test was used for comparison between subgroups. Bold type indicates statistical significance.