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Table 3 Cox regression analysis for overall survival in TNBC

From: Pre-treatment neutrophil to lymphocyte ratio may be a useful tool in predicting survival in early triple negative breast cancer patients

Parameters Univariate Multivariate
p-value HR, 95% CI p-value
Age (≤50 years vs >50 years) 0.06 1.79 (0.04-136.2) 0.68
Menopausal Status (Pre- vs Post-) 0.08 1.18 (0.08-127.6) 0.93
Tumour size (pT1 vs pT2-T3) 0.06 2.10 (0.30-14.4) 0.44
Lymph node status (pN0 vs pN+) 0.05 4.29 (0.65-28.13) 0.13
Nuclear Grade (G1-G2 vs G3) 0.28 0.64 (0.10-3.84) 0.62
Ki-67 (≤20% vs >20%) 0.75 1.49 (0.21-10.30) 0.68
Lympho-vascular invasion (absence vs presence) 0.16 4.95 (0.60-40.30) 0.13
Necrosis (absence vs presence) 0.009 6.92 (1.48-32.35) 0.01
Intraductal carcinoma (absence vs presence) 0.94 1.36 (0.22-8.17) 0.73
NLR (≤3 vs >3) 0.003 6.16 (1.54 – 24.66) 0.01
  1. Table 3 shows a significant correlation between OS and either higher pre-treatment NLR and necrosis.
  2. Legend: NLR = Neutrophil to Lymphocyte Ratio; HR = hazard ratio; CI = confidence interval.