Figure 4
From: Control of the MYC-eIF4E axis plus mTOR inhibitor treatment in small cell lung cancer
MYC and eIF4E silencing increases the sensitivity to everolimus in SBC5 parent cells (SBC5) (A), SBC5 R1 cells (B), and SBC5 R10 cells (C) by MTS assay. Data are expressed as the mean ± SD from 3 independent experiments. (D) Schematic of the results. eIF4F expression can be up-regulated by the PI3K/AKT/mTOR-dependent pathway by p-EGFR activation, PTEN suppression, and SPP1 overexpression. In contrast, MYC directly activates eIF4E expression by an mTOR-independent bypassing pathway.