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Figure 3 | BMC Cancer

Figure 3

From: Control of the MYC-eIF4E axis plus mTOR inhibitor treatment in small cell lung cancer

Figure 3

MYC and eIF4E contribute to the acquired resistance to Everolimus. (A) Protein expression of PI3K/mTOR pathway molecules in SCLC cells by Western blot analysis. p-eIF4E was significantly elevated in the two everolimus-resistant SBC5 cells. (B) Silencing of MYC by two siRNAs in SBC5 cells. p-eIF4E were decreased by si-MYC-A and si-MYC-B at 72 hours. (C) Silencing of MYC by two siRNAs in SBC5 R1 cells in the presence of everolimus 1uM. p-eIF4E protein levels were decreased by the treatments with the two si-MYCs at 48 hours. Eve: Everolimus.

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