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Figure 1 | BMC Cancer

Figure 1

From: Transcriptional expression of 8 genes predicts pathological response to first-line docetaxel + trastuzumab-based neoadjuvant chemotherapy

Figure 1

Data obtained with the analysis of mRNA expression on tumors. A. Correlation between a pCR tumor with a sensitive (HCC2218) and a resistant (HCC1419) cell line for the expression of the 8 genes. The correlation coefficient for this tumor was 0.93 with sensitive cells and −0.36 with resistant cells, thus classifying it as a sensitive tumor. B. Correlation between a non-pCR tumor with a sensitive (BT474) and a resistant (HCC1954) cell line for the expression of the 8 genes. The correlation coefficient for this tumor was −0.25 with sensitive cells and 0.85 with resistant cells, thus classifying it as a resistant tumor. C. Expression levels of the 8 genes in pCR and non-pCR tumors. The expression level of each gene was not significantly different between pCR and non-pCR tumors. The p value was calculated with the non-parametric Mann and Whitney U test. Graphs represent a zoom around the median value, which explains why higher values do not appear on graphs. Median values are indicated by a red solid line.

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