Figure 2

ROC (receiver operating characteristic) curve of combined miRNA analysis. (A) ROC curve of all miRNAs for the score combined from all miRNA (miR-21, miR-34a, miR-125b, miR-155, miR-195, miR-200b, miR-200c, miR-375, miR-451) in discrimination between BC patients and healthy controls. A combined ROC (receiver operating characteristic) curve of all miRNAs showed the excellent AUC (area under the curve) of 0.932 and an optimal sensitivity of 0.917 (95%-CI [0.812; 1.000]) and specifity of 0.917 (95%-CI [0.686; 0.978]), respectively. (B) ROC curve of the four significantly deregulated miRNAs ( miR-21, miR-125b, miR-155, miR-451) was performed and showed high diagnostic accuracy with an AUC of 0.887 and a sensitivity of 0.833 ( 95%-CI [0.697; 0.997]) and specifity of 0.875 (95%-CI [0.640; 0.957]), respectively.