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Table 2 Potential risks associated with IRE of renal tumours

From: The efficacy and safety of irreversible electroporation for the ablation of renal masses: a prospective, human, in-vivo study protocol

Potential hazards of renal IRE ablation

Potential effects

Excessive energy delivery

Muscle contraction, burn, damage to critical anatomical structure, unintended tissue ablated, bradycardia/hypotension, vagal stimulation/asystole, electrical shock, myocardial infarction, stroke, death

Insufficient/no energy delivery

Ineffective ablation, no ablation

Unintended mains or patient circuit voltage exposure to patient or user

Electrical shock

Incorrect timing of pulse delivery

Transient arrhythmia, prolonged arrhythmia, stroke, death

Unintended interference with implanted devices containing electronics or metal parts

Myocardial infarction, stroke, death

Unexpected movement of the device and displacement of the electrodes

Hypotension, damage to critical anatomical structure, pneumothorax, mechanical perforation, haemorrhage, unintended tissue ablated, electrical shock, death

Sterile barrier breach

Infection, sepsis