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Table 1 Age-adjusted incidence rates and incidence rate ratios of small cell lung carcinoma and extrapulmonary small cell carcinoma according to primary site and gender, SEER-13, 1992-2010*

From: A population-based study of incidence and patient survival of small cell carcinoma in the United States, 1992–2010

  ICD-O-3 Males Females Male-to-female
Site topography codes No. IR No. IR IRR (95 % CI)
Total§ 00.0-80.9 28,820 96.20 26,902 71.44 1.35 (1.32, 1.37)
SCLC 34.0-34.9 26,798 89.19 25,161 66.88 1.33 (1.31, 1.36)
EPSCC 00.0-33.9, 35.0-75.9, 77.0-77.9 1,272 4.41 1,166 3.06 1.44 (1.33, 1.56)
Salivary glands 07.9-08.9 44 0.16 <16 ~ ~  
Esophagus 15.0-15.9 106 0.36 81 0.21 1.72 (1.27, 2.33)
Stomach 16.0-16.9 64 0.21 24 0.06 3.46 (2.12, 5.80)
Colon/rectum 18.0-20.9 125 0.42 113 0.30 1.41 (1.08,1.84)
Anus 21.0-21.8 16 0.05 21 0.06 0.95 (0.46, 1.91)
Liver/intrahepatic bile ducts 22.0-22.1 18 0.06 <16 ~ ~  
Gallbladder 23.9 <16 ~ 30 0.08 ~  
Pancreas 25.0-25.9 89 0.30 84 0.22 1.38 (1.01, 1.88)
Nose, nasal cavity, middle ear 30.0-30.1, 31.0-31.9 21 0.07 16 0.04 1.56 (0.77, 3.21)
Larynx 32.0-32.9 37 0.11 27 0.07 1.57 (0.93, 2.68)
Breast 50.0-50.9 <16 ~ 68 0.18 ~  
Vagina 52.9 NA NA 37 0.10 ~  
Cervix 53.0-53.9 NA NA 260 0.69 ~  
Uterus 54.0-55.9 NA NA 56 0.15 ~  
Ovary 56.9 NA NA 111 0.29 ~  
Prostate 61.9 206 0.73 NA NA ~  
Kidney and renal pelvis 64.9, 65.9 22 0.07 <16 ~ ~  
Urinary bladder 67.0-67.9 411 1.48 118 0.30 4.91 (3.99, 6.09)
Unknown primary 76.0-76.8, 80.9 750 2.61 575 1.50 1.73 (1.55, 1.94)
  1. Abbreviations: CI confidence interval, EPSCC extrapulmonary small cell carcinoma, ICD-O-3 third edition of the International Classification of Diseases for Oncology, NA not applicable, No. number of cases, SCLC small cell lung carcinoma, SEER-13 13 cancer registry areas of the Surveillance, Epidemiology and End Results Program, ~ IRs and IRRs are not calculated for <16 cases.
  2. *Incidence rates are age-adjusted to the 2000 U.S. standard population and expressed per 1,000,000 person-years. IRRs are based on unrounded rates.
  3. 95 % CI excludes 1.00 (based on unrounded upper and lower CI), and IRR is significant (P < 0.05).
  4. §Specified sites with 1–15 total cases not shown in the table (ICD-O-3 code): tongue (01.1-0.29), gum and other mouth (03.0-03.9, 05.0-05.9, 06.0-06.9), tonsil (09.0-09.9), oropharynx (10.0-10.9), hypopharynx (12.9, 13.0-13.9), other oral cavity and pharynx (14.0-14.8), small intestine (17.0-17.9), intestinal tract, unspecified (26.0-26.9), soft tissues, including heart (38.0, 47.0-47.9 49.0-49.9), retroperitoneum/peritoneum (48.0-48.8), vulva (51.0-51.9), other female genital (57.0-58.9), testis (62.0-62.9), other male genital (63.0-63.9), ureter (66.9), eye and orbit (69.0-69.9), thyroid (73.9), other endocrine (37.9, 74.0-74.9, 75.0-75.9), and lymph nodes (77.0-77.9). Sites with >15 cases, but with fewer than 16 among both, males and females, not specified in the table (No., IR, ICD-O-3 code): nasopharynx (No. = 23; IR = 0.03; 11.0-11.9), other biliary (No. = 19; IR = 0.03; 24.0-24.9), and trachea/mediastinum/other respiratory (No. = 25; IR = 0.04; 33.9, 38.1-39.9).