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Figure 3 | BMC Cancer

Figure 3

From: Sorafenib inhibits intracellular signaling pathways and induces cell cycle arrest and cell death in thyroid carcinoma cells irrespective of histological origin or BRAF mutational status

Figure 3

Sorafenib induces cell death in thyroid carcinoma cell lines. SW1736, HTh7, BHT101 and ML1 cells were incubated for 14 h and 24 h with 3 μM sorafenib or vehicle (DMSO). LDH release into the cell culture medium was measured using the Cytotox assay (a), and increased caspase 3 and 7 activity was detected using the ApoOne assay (b). Data represent mean values of eight-fold determinations ± standard deviation, and are depicted as percent of vehicle-treated control. *indicates significant increase (p<0.05, Student’s t-test).

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BMC Cancer

ISSN: 1471-2407

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