Figure 2

Cell cycle changes in C643 cells before and after incubation with 3 μM sorafenib for 24 h hours. Cell cycle analysis was conducted using FACS, and this figure shows the complete results for one cell line as an example. Besides the increase in SubG1 peak, in the remaining living cells a decrease in G1 phase and in G2/M-phase and an increase in S-phase of cell cycle was observed. Values for the other cell lines examined are depicted in Table 2.