Study | Stage | Selection criteria | Histology |
---|---|---|---|
ConCerv [11] | IA2, or IB1 | tumor size ≤ 2 cm, No LVSI, and negative margin on cone | SCC, or AC* |
GOG-278 [12] | IA1(LVSI+), IA2, or IB1 | tumor size ≤ 2 cm, negative lateral margins, and depth of invasion ≤ 10 mm on cone | SCC, AC, or ASC |
SHAPE [13] | IA2, or IB1 | tumor size ≤ 2 cm and <50% stromal invasion on MRI, and depth of invasion < 10 mm on cone (if performed) | SCC, AC, or ASC |
MRI | microscopic IB1 | No demonstrable lesion on post-conization MRI | SCC, AC, or ASC |