Table 4 Incidence of adverse events (N = 93)
Adverse event | ≥Grade 1 | ≥Grade 3 | ||
|---|---|---|---|---|
N | % | N | % | |
Neutropenia | 89 | 95.7 | 56 | 60.2 |
Leukopenia | 89 | 95.7 | 22 | 23.7 |
Thrombocytopenia | 12 | 12.9 | 0 | 0 |
Anemia | 44 | 47.3 | 7 | 7.5 |
AST | 27 | 29.0 | 0 | 0 |
ALT | 32 | 34.4 | 1 | 1.1 |
Anorexia | 60 | 64.5 | 6 | 6.5 |
Diarrhea | 59 | 63.4 | 9 | 9.7 |
Nausea | 61 | 65.6 | 0 | 0 |
Stomatitis | 62 | 66.7 | 3 | 3.2 |
Vomiting | 36 | 38.7 | 0 | 0 |
Fatigue | 66 | 71.0 | 5 | 5.4 |
Cholinergic syndrome | 18 | 19.4 | 0 | 0 |
Febrile neutropenia | 1 | 1.1 | 1 | 1.1 |
Sepsis | 2 | 2.2 | 2 | 2.2 |
Interstitial pneumonia | 1 | 1.1 | 0 | 0 |
Hypertension | 10 | 10.8 | 1 | 1.1 |
Bleeding | 7 | 7.5 | 0 | 0 |
Pulmonary artery thrombosis | 1 | 1.1 | 1 | 1.1 |
Pulmonary embolism | 1 | 1.1 | 0 | 0 |
Embolism venous | 1 | 1.1 | 1 | 1.1 |
Gastrointestinal perforation | 2 | 2.2 | 2 | 2.2 |