Table 1 Patient characteristics at baseline (N = 89)
Characteristic | N | % |
|---|---|---|
Sex | ||
Male | 49 | 55.1 |
Female | 40 | 44.9 |
Age | ||
Median | 62 | |
Range | 36-80 | |
ECOG PS | ||
0 | 66 | 74.2 |
1 | 23 | 25.8 |
Primary tumor | ||
Colon | 56 | 62.9 |
Rectum | 33 | 37.1 |
Histological classification | ||
Tubular adenocarcinoma (well-differentiated type) | 27 | 30.3 |
Tubular adenocarcinoma (moderately-differentiated type) | 50 | 56.2 |
Poorly-differentiated adenocarcinoma | 9 | 10.1 |
Mucinous adenocarcinoma | 3 | 3.4 |
Number of metastatic sites | ||
1 | 37 | 41.6 |
2≤ | 52 | 58.4 |
UGT1A1*28/*6 polymorphism | ||
Wild-type group | 52 | 58.4 |
Heterozygous group | 37 | 41.6 |
First-line treatment | ||
Refractory (PD) / intolerable (adverse event) to oxaliplatin-based treatment | 46/43 | 51.7/48.3 |
With/without bevacizumab | 69/20 | 77.5/22.5 |